AutoMedBench: Towards Medical AutoResearch with Agentic AI Models

Autonomous agents are increasingly expected to support end-to-end medical-AI research workflows, moving beyond isolated prediction tasks or short-form clinical question answering. However, existing medical agent benchmarks primarily evaluate final outputs, providing limited visibility into agent behavior within the research process. To address this gap, we present AutoMedBench, a workflow-aware benchmark for autonomous medical-AI research across diverse medical imaging and multimodal inference tasks, organizing agent execution into a unified five-stage workflow (S1-S5): Plan, Setup, Validate, Inference, and Submit. It comprises long-horizon tasks with each run averaging 33 agent turns, spanning five research tracks: segmentation, image enhancement, visual question answering (VQA), report generation, and lesion detection. Each task is evaluated under two difficulty tiers, Lite and Standard, which use the same data and metrics but differ in the amount of task-brief scaffolding, and each run is scored using both final task performance and S1-S5 stage scores, enabling stage-level analysis from the initial task brief to the final submitted artifact. Across thousands of recorded runs, stage-level scoring reveals that Validate is the weakest workflow stage on average, whereas Setup is the strongest, suggesting that current agents are better at making pipelines executable than at verifying their reliability. Post-run error analysis further shows that verification and submission failures dominate tagged errors, accounting for 37.7% and 38.1% of fired codes respectively, whereas task-understanding errors are rare at 0.9%, and runs with one fired error code have a 48% lower overall score than runs with no error code on average.

G2LoRA: Gradient Orthogonal Low-Rank Adaptation Framework for Graph Continual Learning on Text-Attributed Graphs

LLM-as-Aligner has emerged as a prevalent pre-training paradigm for Text-Attributed Graphs(TAGS), aligning graph and text modalities into a shared embedding space via CLIP-style contrastive learning. While effective on individual downstream tasks, we observe severe catastrophic forgetting when such models are sequentially fine-tuned on streaming tasks. Although parameter-efficient fine-tuning alleviates forgetting to some extent, it remains insufficient to resolve task interference and ineffective knowledge transfer. In this work, we study graph continual learning for LLM-as-Aligner models on TAGs, with the goal of mitigating interference while promoting positive transfer across tasks. This setting introduces two fundamental challenges: (1) heterogeneous downstream tasks induce shifting optimization objectives, hindering unified fine-tuning; and (2) graph and text encoders exhibit different sensitivities to adaptation, making uncoordinated updates prone to misalignment. To address these challenges, we propose G2LoRA, a continual learning framework for TAGs. G2LoRA unifies node-, link-, and graph-level tasks under a single graph--text alignment objective, and enables consistent optimization across domain/class/task incremental modes. To reduce task interference while encouraging positive transfer, G2LoRA performs category-aware gradient projection in structured subspaces, resolving conflicting updates and enabling conditional backward transfer to balance forward and backward knowledge flow. To further prevent cross-modal drift, G2LoRA introduces gradient magnitude modulation to coordinate update rates between graph and text encoders. Extensive experiments on benchmark datasets demonstrate that G2LoRA consistently outperforms strong baselines across different backbone architectures, achieving superior continual performance and transferability.

Seeing Before Agreeing: Aligning Multi-Agent Consensus with Visual Evidence

Vision-language models (VLMs) have achieved strong performance on visual question answering (VQA). To mitigate individual hallucinations and blind spots, aggregating diverse perspectives via multi-agent collaboration has emerged as a promising paradigm. While this approach has shown great success in textual QA, its potential in the multimodal domain remains under-explored. Existing multi-agent VQA methods predominantly adapt text-centric protocols, focusing on textual discussions while ignoring the alignment of visual information. In this work, we reveal a key insight: answer-level agreement is insufficient for reliable multi-agent VQA; \textit{aligned visual evidence} -- shared support from the image regions agents rely on -- is essential for trustworthy consensus. To leverage this insight, we propose EAGLE (\textbf{E}vidence-\textbf{A}ligned \textbf{G}rounded mu\textbf{L}ti-agent r\textbf{E}asoning), a training-free evidence-centered framework for coordinating multiple VLM agents. EAGLE explicitly exposes each agent's grounding regions as visual evidence, enables mutual verification over the evidence, and uses evidence consistency to guide final decision-making. Experiments on six VQA benchmarks show that EAGLE achieves best average performance across domains while remaining lightweight, interpretable, and practical for deployment.

S2Aligner: Pair-Efficient and Transferable Pre-Training for Sparse Text-Attributed Graphs

Pre-training on text-attributed graphs (TAGs) is central to building transferable graph foundation models, where LLM-as-Aligner methods align graph and text representations through the semantic knowledge of large language models. However, these methods usually assume that node texts provide sufficient and reliable supervision, an assumption often violated in real-world sparse TAGs. When textual anchors are missing, noisy, or uneven across domains, graph structures must be aligned with weak semantic evidence, leading to unreliable structure-semantics correspondence and sparsity-induced transfer bias. This paper presents S2Aligner, a sparsity-aware and structure-enhanced LLM-as-Aligner framework for graph-text pre-training on sparse TAGs. The key idea is to decouple semantic alignment from structural modeling, allowing topology-aware signals to enhance alignment without contaminating the shared semantic space. Specifically, S2Aligner decomposes graph-text representations into semantic and structural components, uses structure-oriented reconstruction with consistency control to inject reliable topology cues into text representations, and suppresses inconsistent structural signals under textual sparsity. Moreover, S2Aligner introduces sparsity-aware cross-domain risk balancing, which calibrates domain risks through a global-domain density ratio and downweights unreliable sparse samples via graph reliability estimation. Theoretical analysis shows that this objective reduces cross-domain generalization gaps by controlling domain risk discrepancy. Extensive experiments across diverse graph domains, sparsity levels, and downstream tasks demonstrate that S2Aligner consistently outperforms existing baselines.

ClinSeekAgent: Automating Multimodal Evidence Seeking for Agentic Clinical Reasoning

Large language models (LLMs) and agentic systems have shown promise for clinical decision support, but existing works largely assume that evidence has already been curated and handed to the model. Real-world clinical workflows instead require agents to actively seek, iteratively plan, and synthesize multimodal evidence from heterogeneous sources. In this paper, we introduce ClinSeekAgent, an automated agentic framework for dynamic multimodal evidence seeking that shifts the paradigm from passive evidence consumption to active evidence acquisition. Given only a clinical query and access to raw data sources, ClinSeekAgent gathers evidence by querying medical knowledge bases, navigating raw EHRs, and invoking medical imaging tools; refines its hypotheses as new information emerges; and integrates the collected evidence into grounded clinical decisions. ClinSeekAgent serves both as an inference-time agent for frontier LLMs and as a training-time pipeline for distilling high-quality agent trajectories into compact open-source models. To validate its inference-time effectiveness, we construct ClinSeek-Bench, which pairs Curated Input reasoning from fixed pre-selected evidence with Automated Evidence-Seeking over raw clinical data. On text-only EHR tasks, ClinSeekAgent improves Claude Opus 4.6 from 60.0 to 63.2 overall F1 and MiniMax M2.5 from 43.1 to 47.3, with positive risk-prediction gains in 7 out of 9 evaluated host models. On multimodal tasks, ClinSeekAgent improves Claude Opus 4.6 from 47.5 to 62.6 (+15.1); all evaluated models improve across the three CXR-related task groups. We further validate ClinSeekAgent as a training pipeline by distilling agentic evidence-seeking trajectories into ClinSeek-35B-A3B, which achieves 34.0 average F1 on existing AgentEHR-Bench, improving over its Qwen3.5-35B-A3B baseline by +11.9 points and approaching Claude Opus 4.6.

Divergence Meets Consensus: A Multi-Source Negative Sampling Framework for Sequential Recommendation

Negative sampling is significant for training sequential recommendation models under implicit feedback. The predominant strategy, self-guided hard negative sampling, selects negatives based on the model's current state but suffers from three limitations: (1) the coupling between sampling and model updates triggers a vicious cycle that drives the model into local optima; (2) relying on current model parameters narrows sampling to a small region of the item space, reducing diversity and harming generalization; (3) identifying a hard negative requires scoring the entire candidate pool, causing substantial computational overhead with minimal information gain. To address these challenges, we propose MDCNS (Multi-source Divergence-Consensus for Negative Sampling), a novel "Teacher-Peer-Self" framework inspired by Vygotsky's Zone of Proximal Development (ZPD) theory. The proposed method comprises three components, including multi-source scoring, divergence re-ranking, and consensus distillation. Firstly, multi-source scoring incorporates peer and ensemble teacher models to inject external negative signals and break the self-reinforcement loop. Then, divergence re-ranking exploits prediction discrepancy between self and peer models to enhance sampling diversity. Finally, consensus distillation aligns the self model with the teacher via KL divergence, simultaneously improving computational cost utilization. Extensive experiments on six real-world datasets and five backbone models show that MDCNS consistently outperforms state-of-the-art negative sampling methods, demonstrating strong effectiveness and generalization.

Graph-Based Financial Fraud Detection with Calibrated Risk Scoring and Structural Regularization

Financial transaction fraud prevention faces challenges such as complex relationship structures, concealed behavioral patterns, and dynamically changing data distribution. Discrimination models relying solely on independent sample features are insufficient to fully characterize the risks of group collaboration and chain transfers within transaction networks. This paper proposes a graph neural network representation learning and risk discrimination framework for financial transaction fraud prevention. It integrates transaction records and identity information into node attributes and constructs a transaction graph based on shared attributes and interaction consistency to explicitly model inter-transaction relationships. In model design, a multi-layer message passing mechanism is employed to aggregate neighborhood information, learn node embedding representations containing structural context semantics, and output transaction-level fraud probability and risk scores through a lightweight risk discrimination head. A weighted supervision objective is introduced to mitigate training bias caused by class imbalance, and structural consistency regularization constraints are combined to suppress the impact of noisy edges on representation drift, thereby improving the stability and usability of risk characterization. Experiments are conducted on a publicly available financial transaction dataset, comparing various methods in the same direction and comprehensively evaluating them under a unified evaluation protocol. The results show that the proposed method outperforms other methods in risk ranking and probability calibration quality, validating the effectiveness of graph structure modeling and representation learning collaboration in financial transaction fraud prevention.

Any2Any 3D Diffusion Models with Knowledge Transfer: A Radiotherapy Planning Study

Voxel-wise dose prediction is a critical yet challenging task in practical radiotherapy (RT) planning, as bespoke models trained from scratch often struggle to generalize across diverse clinical settings. Meanwhile, generative models trained on billion-scale datasets from vision domains have achieved impressive performance. Herein, we propose DiffKT3D, a unified Any2Any 3D diffusion framework that leverages prior knowledge from pretrained video diffusion models for efficient and clinically meaningful dose prediction. To enable flexible conditioning across multiple clinical modalities (CT, anatomical structures, body, beam settings, etc.), we introduce an Any2Any conditional paradigm utilizing modality-specific embeddings without cross-attention overhead. Further, we design a novel reinforcement learning (RL) post-training mechanism guided by a clinically-informed Scorecard explicitly tailored to institutional treatment preferences. Compared with winner of GDP-HMM challenge, DiffKT3D sets a new state-of-the-art in dose prediction by reducing voxel-level MAE from 2.07 to 1.93. In addition, DiffKT3D achieves superior image quality and preference match. These results demonstrate that transferring diffusion priors via modality-aware conditioning and clinically aligned RL post-training can provide a robust and generalizable solution for RT planning across various clinical scenarios.

Kestrel: Grounding Self-Refinement for LVLM Hallucination Mitigation

Large vision-language models (LVLMs) have become increasingly strong but remain prone to hallucinations in multimodal tasks, which significantly narrows their deployment. As training these LVLMs to avoid hallucinations becomes prohibitively expensive for larger models, training-free methods offer a cheap and flexible solution to this problem, yet existing approaches based on decoding or tool use often bring limited gains and/or weak interpretability. We propose Kestrel, a training-free framework for LVLM hallucination mitigation that combines an explicit visual-grounding agent with evidence-verified self-refinement mechanism. In detail, Kestrel first collects explicit visual evidence and converts tool outputs into reusable and structured textual evidence. Second, to take full advantage of these evidence, Kestrel verifies them via an LVLM judge for evidence checking, then iteratively self-refine answers based on verified evidence to reduce the risk of over-correction. Extensive experiments show that Kestrel improves performance over strong baselines across hallucination benchmarks (e.g., average +3.31% on POPE and +28.34 on MME-Hallucination with Qwen3-VL), while providing transparent verification traces for hallucination diagnosis and analysis -- e.g., both the integrated self-refinement module and grounding agent contributing an average +2.0% gain on POPE.

Modeling and Benchmarking Spoken Dialogue Rewards with Modality and Colloquialness

The rapid evolution of end-to-end spoken dialogue systems demands transcending mere textual semantics to incorporate paralinguistic nuances and the spontaneous nature of human conversation. However, current methods struggle with two critical gaps: the modality gap, involving prosody and emotion, and the colloquialness gap, distinguishing written scripts from natural speech. To address these challenges, we introduce SDiaReward, an end-to-end multi-turn reward model trained on SDiaReward-Dataset, a novel collection of episode-level preference pairs explicitly targeting these gaps. It operates directly on full multi-turn speech episodes and is optimized with pairwise preference supervision, enabling joint assessment of modality and colloquialness in a single evaluator. We further establish ESDR-Bench, a stratified benchmark for robust episode-level evaluation. Experiments demonstrate that SDiaReward achieves state-of-the-art pairwise preference accuracy, significantly outperforming general-purpose audio LLMs. Further analysis suggests that SDiaReward captures relative conversational expressiveness beyond superficial synthesis cues, improving generalization across domains and recording conditions. Code, data, and demos are available at https://sdiareward.github.io/.